Concordance of confirmatory prostate biopsy in active surveillance with national guidelines: An analysis from the multi-institutional PURC cohort.

PURPOSE: National Comprehensive Cancer Network (NCCN) guidelines recommend confirmatory biopsy within 12 months of active surveillance (AS) enrollment. With <10 cores on initial biopsy, re-biopsy should occur within 6 months. Our objective was to determine if patients on AS within practices in the Pennsylvania Urologic Regional Collaborative (PURC) receive guideline concordant confirmatory biopsies. MATERIALS AND METHODS: Within PURC, a prospective collaborative of diverse urology practices in Pennsylvania and New Jersey, we identified men enrolled in AS after first biopsy, analyzing time to re-biopsy and factors associated with various intervals of re-biopsy. RESULTS: In total, 1,047 patients were enrolled in AS for a minimum of 12 months after initial biopsy. Four hundred seventy-seven (45%) underwent second biopsy at 1 of the 9 PURC practices. The number of patients undergoing re-biopsy within 6 months, 6 to 12 months, 12 to 18 months, and >18 months was 71 (14%), 218 (45.7%), 134 (28%), and 54 (11%), respectively. Sixty percent underwent confirmatory biopsy within 12 months. On multivariate analysis, re-biopsy interval was associated with number of positive cores, perineural invasion, and practice ID (all P < 0.05). Adjusted multivariable regression did not identify factors predictive of re-biopsy interval. CONCLUSION: Of patients who underwent confirmatory biopsy at PURC practices, 60.5% were within 12 months per NCCN guidelines. This suggests area for improvement in guideline adherence after enrollment in AS. All practices that offer AS should periodically perform similar analyses to monitor their performance. In an era of value-based care, adherence to guideline based active surveillance practices may eventually comprise national quality metrics affecting provider reimbursement.

Historical and Current Practices in the Management of Fossa Navicularis Strictures.

PURPOSE OF REVIEW: Fossa navicularis strictures represent a surgically challenging disease process that requires detailed preoperative planning and an understanding of each patient's goals in order to achieve a satisfactory long-term outcome. This review summarizes the various approaches used in the management of fossa navicularis strictures over the past several decades. RECENT FINDINGS: In addition to existing evidence to support open flap- and graft-based reconstruction, recent studies suggest a potential role for limited open repair via a transurethral approach. Open repair of fossa navicularis strictures has become the standard of care with high success rates using local skin flaps or tissue grafts. There remains a very limited role for minimally invasive techniques in definitive management of this disease.

Chairmen in Academic Urologic Practice: A Descriptive Analysis.

OBJECTIVE: To examine and characterize the demographics and scholarly characteristics of academic urology chairmen at the time of appointment. MATERIALS AND METHODS: The chairman of each United States urology residency program as of September 2016 was included in the study. Interim chairmen, as well as programs for which no clearly defined chair could be identified, were excluded. Demographic and academic data were collected via publically available curriculum vitae, departmental websites, Google search engine, and PubMed and Scopus websites. RESULTS: One hundred thirteen chairmen were included in the study. The majority were male (96%) and mean age at appointment was 46 years (standard deviation = 6.3 years). Mean number of publications and H-index at the time of appointment was 105 and 31.1, respectively. Fellowship training was completed by 75% of chairmen, of which urologic oncology (N = 43), endourology (N = 12), and infertility/andrology (N = 10) were the most common. The most common additional graduate degrees prior to appointment were MBA (N = 7) and PhD (N = 6). The most frequently attended institutions for residency were Johns Hopkins University (13) and Northwestern University (5), whereas Memorial Sloan Kettering Cancer Center (13) and Baylor University (7) were the most frequent for fellowship. Twenty percent of chairmen attained the chairman position at their former residency program and 7% at their former fellowship program. CONCLUSION: Our study describes the demographic and academic characteristics of urology academic chairmen at the time of appointment. The majority of chairmen are male and specialize in urologic oncology. Chairmen often receive the chair appointment at their former residency program.

Group status drives majority and minority integration preferences.

This research examined preferences for national- and campus-level assimilative and pluralistic policies among Black and White students under different contexts, as majority- and minority-group members. We targeted attitudes at two universities, one where 85% of the student body is White, and another where 76% of students are Black. The results revealed that when a group constituted the majority, its members generally preferred assimilationist policies, and when a group constituted the minority, its members generally preferred pluralistic policies. The results support a functional perspective: Both majority and minority groups seek to protect and enhance their collective identities.

A systematic review of occipital cervical fusion: techniques and outcomes.

OBJECT Numerous techniques have been historically used for occipitocervical fusion with varied results. The purpose of this study was to examine outcomes of various surgical techniques used in patients with various disease states to elucidate the most efficacious method of stabilization of the occipitocervical junction. METHODS A literature search of peer-reviewed articles was performed using PubMed and CINAHL/Ovid. The key words "occipitocervical fusion," "occipitocervical fixation," "cervical instrumentation," and "occipitocervical instrumentation" were used to search for relevant articles. Thirty-four studies were identified that met the search criteria. Within these studies, 799 adult patients who underwent posterior occipitocervical fusion were analyzed for radiographic and clinical outcomes including fusion rate, time to fusion, neurological outcomes, and the rate of adverse events. RESULTS No articles stronger than Class IV were identified in the literature. Among the patients identified within the cited articles, the use of posterior screw/rod instrumentation constructs were associated with a lower rate of postoperative adverse events (33.33%) (p < 0.0001), lower rates of instrumentation failure (7.89%) (p < 0.0001), and improved neurological outcomes (81.58%) (p < 0.0001) when compared with posterior wiring/rod, screw/plate, and onlay in situ bone grafting techniques. The surgical technique associated with the highest fusion rate was posterior wiring and rods (95.9%) (p = 0.0484), which also demonstrated the shortest fusion time (p < 0.0064). Screw/rod techniques also had a high fusion rate, fusing in 93.02% of cases. When comparing outcomes of surgical techniques depending on the disease status, inflammatory diseases had the lowest rate of instrumentation failure (0%) and the highest rate of neurological improvement (90.91%) following the use of screw/rod techniques. Occipitocervical fusion performed for the treatment of tumors by using screw/rod techniques had the lowest fusion rate (57.14%) (p = 0.0089). Traumatic causes of occipitocervical instability had the highest percentage of pain improvement with the use of screw/plates (100% improvement) (p < 0.0001). CONCLUSIONS Based on the existing literature, techniques that use screw/rod constructs in occipitocervical fusion are associated with very favorable outcomes in all categories assessed for all disease processes. For patients requiring occipitocervical arthrodesis for the treatment of inflammatory diseases, screw/rod constructs are associated with the most favorable outcomes, while posterior wiring and onlay in situ bone grafting is associated with the least favorable outcomes. Occipitocervical arthrodesis performed for the diagnosis of tumor is associated with the lowest rate of successful arthrodesis using screw/rod techniques, while posterior wiring and rods have the highest rate of arthrodesis. The nonspecified disease group had the lowest rate of surgical adverse events and the highest rate of neurological improvement.

Injury of the posterior ligamentous complex of the thoracolumbar spine: a prospective evaluation of the diagnostic accuracy of magnetic resonance imaging.

STUDY DESIGN: Prospective diagnostic imaging study. OBJECTIVE: To determine the accuracy of magnetic resonance imaging (MRI) in diagnosing injury of the posterior ligamentous complex (PLC) in patients with thoracolumbar trauma. SUMMARY OF BACKGROUND DATA: Treatment decisions in thoracolumbar injury patients are currently based on the status of the PLC. It is, therefore, important to understand the accuracy of MRI in diagnosing varying degrees of PLC injury. Prior studies report that MRI is up to 100% sensitive for diagnosing PCL injury. METHODS: Patients with an acute injury from T1 to L3 who required posterior surgery were prospectively studied. A musculoskeletal radiologist, based on the preoperative MRI findings, characterized each of the 6 components of the PLC as intact, incompletely disrupted, or disrupted. During the surgical procedure, the surgeon identified each component of the PLC as intact, incompletely disrupted, or disrupted. The radiologist's interpretation and surgical findings were compared. RESULTS: Forty-two patients with 62 levels of injury were studied. There were 33 males (78.6%) and 9 females (21.4%), and the average age was 35.7 years. According to the kappa score, there was a moderate level of agreement between the radiologist's interpretation and the intraoperative findings for all PLC components except the thoracolumbar fascia, for which there was slight agreement. The sensitivity for the various PLC components ranged from 79% (left facet capsule) to 90% (interspinous ligament). The specificity ranged from 53% (thoracolumbar fascia) to 65% (ligamentum flavum). There was less agreement between the radiologist and surgeon for the patients with less severe neurologic compromise, i.e., those patients with an AIS grade of either D or E. CONCLUSION: The sensitivity and specificity of MRI for diagnosing injury of the PLC are lower than previously reported in the literature. The integrity of the PLC as determined by MRI should not be used in isolation to determine treatment.

Complications in the management of Charcot spinal arthropathy.

Charcot spinal arthropathy is a relatively rare, destructive process characterized by a cycle of progressive deformity, destruction, and worsening instability as a result of repetitive trauma and inflammation. It may result from nontraumatic as well as traumatic causes. Historically, patients with severe symptomatic instability have been successfully treated with combined anterior and posterior fusion techniques. The long-term outcomes and potential complications, however, have not been well reported. The authors report on 2 such cases of Charcot spinal arthropathy treated surgically, one with a traumatic and one with a nontraumatic etiology. They include the unique pitfalls encountered while treating these patients, as well as their surgical treatments, complications, and long-term results.

Nonoperative treatment of symptomatic spondylolysis.

SUMMARY OF BACKGROUND DATA: Symptomatic spondylolysis resulting from a stress fracture of the pars interarticularis is a cause of low back pain in the juvenile and adolescent patient. Treatment is conservative in the majority of cases. OBJECTIVE: To analyze the outcome of patients with symptomatic isthmic spondylolysis treated nonoperatively with a custom fit thoracolumbar orthosis and activity cessation for 3 months followed by an organized physical therapy program. STUDY DESIGN: Retrospective case series. PATIENT SAMPLE: Four hundred thirty-six juvenile and adolescent patients with spondylolysis. OUTCOME MEASURES: Pain improvement, hamstring flexibility, range of motion, resolution of back spasms, and return to previous activities. METHODS: Retrospective review of 436 juvenile and adolescent patients with symptomatic spondylolysis confirmed by single-photon emission computed tomography or computed tomography. Clinical outcomes were assessed through patient history and physical examination. RESULTS: Ninety-five percent of patients achieved excellent results according to a modified Odom's Criteria. The remaining 5% of patients achieved good results as they required occasional nonsteroidal anti-inflammatory drugs to relieve pain. Back spasms were resolved and hamstring tightness and range of motion returned to normal in all patients. All patients returned to their preinjury activity level. No patients went on to surgery. CONCLUSIONS: Symptomatic juvenile and adolescent patients with an isthmus spondylolysis may be effectively managed with a custom fit thoracolumbar orthosis brace and activity cessation for approximately 3 months followed by an organized physical therapy program.

Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion.

Since the identification of the osteogenic protein-1 (OP-1) gene, also called bone morphogenetic protein-7 (BMP-7), almost 20 years ago, OP-1 has become one of the most characteristic members of the BMP family. The biological activity of recombinant human OP-1 has been defined using a variety of animal models. These studies have demonstrated that local implantation of OP-1 in combination with a collagen matrix results in the repair of critical size defects in long bones and in craniofacial bones and the formation of bony fusion masses in spinal fusions. Clinical trials investigating long bone applications have provided supportive evidence for the use of OP-1 in the treatment of open tibial fractures, distal tibial fractures, tibial nonunions, scaphoid nonunions and atrophic long bone nonunions. Clinical studies investigating spinal fusion applications have provided supportive evidence for the use of OP-1 in posterolateral lumbar models and compromised patients as an adjunct or as a replacement for autograft. Both long bone repair and spinal fusion studies have demonstrated the efficacy and safety of OP-1 by clinical outcomes and radiographic measures. Future clinical investigations will be needed to better define variables, such as dose, scaffold and route of administration. Clearly the use of BMPs in orthopaedics is still in its formative stage, but the data suggest an exciting and promising future for the development of new therapeutic applications.